$ALNY

PYOTT DAVID E I sold $351K of ALNY

PYOTT DAVID E I sold 1,175 shares of ALNYLAM PHARMACEUTICALS, INC. (ALNY) at $298.91 ($0.35M total) on 2026-06-01 under a Rule 10b5-1 trading plan.

Original reporting
SEC EDGAR · PYOTT DAVID E I
Published Jun 3, 2026, 8:25 PM UTC
Analysis
alphai AI DeskAI-generated
Added to alphai Jun 3, 2026, 8:36 PM UTC. Informational, not investment advice.
How this was made
alphai summarizes source reporting and applies a structured AI analysis for relevance, timing, sentiment and ticker impact. Always verify material claims with the original publisher.
alphai market briefInsider activity
Primary signal
$ALNY
Neutral
medium confidence
Mentioned
$ALNY
Relevance
6/10
alphai data visualization · based on SEC EDGAR
Decision brief

The 30-second read

$ALNYNeutralLow
01

Why it matters

The disclosure may marginally influence sentiment, but it is not a fundamental catalyst by itself.

02

Market read

A single director sale under a 10b5-1 plan is generally low-impact; traders may treat it as background noise unless paired with other negative catalysts.

03

What to watch

The article doesn’t state whether the director’s total holdings changed materially over time or whether other insiders/funds made offsetting moves.

Relevance 6/10Novelty 3/10Timing: SEC Form 4 filed today; sale executed 2026-06-01

Background

This is an SEC Form 4 insider transaction disclosure (director; open-market sale) including execution details and confirmation of a pre-arranged 10b5-1 plan.

Company-level read

Ticker impact

$ALNYNeutralMedium confidence
Context

Alnylam’s director sold 1,175 shares in an open-market transaction under a pre-arranged 10b5-1 plan, disclosed via SEC Form 4.

Expected impact

Likely limited, short-lived impact; any move would be dominated by broader biotech catalysts rather than this Form 4.

Evidence & confidence

The filing provides a specific sale price/date and confirms a pre-arranged 10b5-1 plan, which reduces the likelihood of information-driven trading.

Market effects

Minimal—this is company-specific insider activity with no stated operational/clinical/regulatory change.

None indicated.

None indicated.

Counterpoint

Even with a 10b5-1 plan, repeated insider selling can coincide with periods of valuation risk or portfolio rebalancing; monitor for clustering of similar filings.

Key entities

  • ALNY

    Alnylam Pharmaceuticals, Inc.; issuer of the insider Form 4 transaction.

  • PYOTT DAVID E I

    Director who sold 1,175 shares on 2026-06-01 under a 10b5-1 plan.

Related articles

$ALNYMedAI 8/10

Alnylam (ALNY) Q2 2026 Earnings Call Transcript

Alnylam (ALNY) reported Q2 2026 net product revenues of $1.2B, up 74%, driven by AMVUTTRA uptake in ATTR cardiomyopathy. TTR net product revenues were $1.03B, up 89%, and the company raised AMVUTTRA run rate to over $4B annually. It lowered 2026 product guidance to $4.7B-$5.1B and revised collaboration/royalty guidance to $575M-$625M.

$ALNYMed

Why is Alnylam Pharmaceuticals stock climbing today?

Alnylam Pharmaceuticals shares rose 1.7% in pre-open to $209.1 after Raymond James upgraded the stock from Outperform to Strong Buy and set a $420 price target. The upgrade followed a post–Q2 selloff tied to reduced ATTR franchise guidance. Other banks issued constructive notes. The S&P 500 and Dow were up.

$ALNYHighAI 9/10

Alnylam: AMVUTTRA Revenue Tops $1 Billion, But Pent-Up Demand Normalization Triggers Guidance Cut

Alnylam reported Q2 2026 AMVUTTRA net product revenue of $1.01B, up 106% year over year, and total quarterly product revenue of $1.17B. Combined TTR revenue was $1.03B. Despite results, Alnylam cut 2026 TTR product revenue guidance to $4.2B-$4.5B and total net product revenue to $4.7B-$5.1B, citing normalization of second-line demand. Total Q2 revenue rose to $1.29B.

$ALNYHighAI 9/10

Alnylam plunges as earnings deliver ‘one-two punch’

Alnylam Pharmaceuticals shares fell nearly 30% after the company lowered 2026 revenue guidance for its transthyretin amyloidosis drugs Amvuttra and Onpattro by $200 million. The estimate was cut to $4.2 billion to $4.5 billion from $4.4 billion to $4.7 billion, citing normalized demand after an early launch spike. Amvuttra quarterly sales were $1.01 billion.

$ALNYMed

ALNYLAM PHARMACEUTICALS, INC. INVESTOR ALERT: Kirby McInerney LLP Announces Investigation Into Potential Securities Fraud

Kirby McInerney LLP said it is investigating potential securities fraud claims involving Alnylam Pharmaceuticals (NASDAQ: ALNY). The probe follows Alnylam’s July 30, 2026 Q2 results, including lowered full-year 2026 TTR product sales guidance and a roughly $200 million reduction in projected TTR net product revenues. Alnylam shares fell about 28% to $205.48.

$MSFTHighAI 8/10

Stocks Rally on Stellar Microsoft Earnings and Chip Stock Strength

US stocks rose as investors digested strong Q2 earnings expectations and results, led by Microsoft. The article cites Bloomberg Intelligence forecasts for Q2 earnings up about 23% and notes 86% of 243 S&P 500 firms beat estimates. It also reports chip and AI-infrastructure gains tied to Lam Research and other semis, while some software names fell.