$ALNY

PYOTT DAVID E I sold $351K of ALNY

PYOTT DAVID E I sold 1,175 shares of ALNYLAM PHARMACEUTICALS, INC. (ALNY) at $298.91 ($0.35M total) on 2026-06-01 under a Rule 10b5-1 trading plan.

Original reporting
SEC EDGAR · PYOTT DAVID E I
Published Jun 3, 2026, 8:25 PM UTC
Analysis
AlphAI AI DeskAI-generated
Added to AlphAI Jun 3, 2026, 8:36 PM UTC. Informational, not investment advice.
How this was made
AlphAI summarizes source reporting and applies a structured AI analysis for relevance, timing, sentiment and ticker impact. Always verify material claims with the original publisher.
AlphAI market briefInsider activity
Primary signal
$ALNY
Neutral
medium confidence
Mentioned
$ALNY
Relevance
6/10
AlphAI data visualization · based on SEC EDGAR
Decision brief

The 30-second read

$ALNYNeutralLow
01

Why it matters

The disclosure may marginally influence sentiment, but it is not a fundamental catalyst by itself.

02

Market read

A single director sale under a 10b5-1 plan is generally low-impact; traders may treat it as background noise unless paired with other negative catalysts.

03

What to watch

The article doesn’t state whether the director’s total holdings changed materially over time or whether other insiders/funds made offsetting moves.

Relevance 6/10Novelty 3/10Timing: SEC Form 4 filed today; sale executed 2026-06-01

Background

This is an SEC Form 4 insider transaction disclosure (director; open-market sale) including execution details and confirmation of a pre-arranged 10b5-1 plan.

Company-level read

Ticker impact

$ALNYNeutralMedium confidence
Context

Alnylam’s director sold 1,175 shares in an open-market transaction under a pre-arranged 10b5-1 plan, disclosed via SEC Form 4.

Expected impact

Likely limited, short-lived impact; any move would be dominated by broader biotech catalysts rather than this Form 4.

Evidence & confidence

The filing provides a specific sale price/date and confirms a pre-arranged 10b5-1 plan, which reduces the likelihood of information-driven trading.

Market effects

Minimal—this is company-specific insider activity with no stated operational/clinical/regulatory change.

None indicated.

None indicated.

Counterpoint

Even with a 10b5-1 plan, repeated insider selling can coincide with periods of valuation risk or portfolio rebalancing; monitor for clustering of similar filings.

Key entities

  • ALNY

    Alnylam Pharmaceuticals, Inc.; issuer of the insider Form 4 transaction.

  • PYOTT DAVID E I

    Director who sold 1,175 shares on 2026-06-01 under a 10b5-1 plan.

Full insider trading history

This story covers one filing. See everything behind it: every insider buy and sell on record, 10b5-1 plans, late filings, and which officers and directors are trading.

Related articles

$ALNYMed

ALNY Stock Rebounds As Analysts Back RNAi Momentum

Alnylam Pharmaceuticals (ALNY) stock rose 8.51% on positive RNAi pipeline updates and analyst upgrades. Analysts set price targets ranging from $318 to $455, citing strong clinical data and growth prospects. The company reported $3.71B in trailing revenue, a 92.1% gross margin, and positive EBIT margin of 23.4%.

$ALNYHighAI 8/10

Alnylam’s RNA Silencing Drugs Stay In The Fight For ATTR-CM Patients Despite AstraZeneca Setback

AstraZeneca (AZN) and Ionis Pharmaceuticals (IONS) discontinued a phase 3 trial for Wainua, a combination therapy for ATTR-CM. Analysts debate whether Alnylam Pharmaceuticals (ALNY) can succeed with its RNA silencing drugs in this area. ALNY's drugs are being considered for use with standard TTR stabilizers, targeting the disease through different pathways. The outcome may impact the ATTR-CM market and RNA therapeutics sector.

$ALNYMedAI 8/10

Alnylam Pharmaceuticals, Inc.: Alnylam Presents New Data at ESC Congress 2026 Reinforcing Strength in RNAi-Powered TTR Silencing Across ATTR-CM Patient Populations and Treatment Settings

Alnylam Pharmaceuticals (ALNY) presented new data at ESC Congress 2026, showing consistent clinical benefits of vutrisiran across ATTR-CM patient populations and treatment settings. Additional analyses highlighted the potential of vutrisiran in addressing multisystemic manifestations of ATTR-CM and the consistent treatment effects of RNAi-powered TTR silencing across sexes. The company also presented data on zilebesiran, an investigational RNAi therapeutic for uncontrolled hypertension, showing

$ALNYHighAI 8/10

IONS, AZN Stocks Fall On Full Data From Failed Cardiomyopathy Trial — Jefferies Sees Neutral To Negative Readthrough To ALNY

Ionis (IONS) and AstraZeneca (AZN) presented full data from a failed trial of Wainua for transthyretin amyloid cardiomyopathy (ATTR-CM). Jefferies sees neutral to negative implications for Alnylam (ALNY), which is developing similar drugs. ALNY shares closed flat, IONS down 2%, and AZN down 1% on Friday. The trial missed its primary goal, raising doubts about ALNY's TTR business.