Summit Therapeutics reports Phase III overall‑survival win for ivonescimab in advanced biliary tract cancer
Summit Therapeutics announced that its bispecific antibody ivonescimab combined with chemotherapy achieved a statistically significant overall‑survival advantage over durvalumab plus chemotherapy in the HARMONi‑GI1 Phase III trial of first‑line advanced biliary tract cancer. Median overall survival was 14.9 months versus 12.1 months, corresponding to a hazard ratio of 0.75 (25% reduction in death risk). The regimen also improved median progression‑free survival to 8.4 months versus 5.8 months and raised objective response and disease‑control rates to 53.8%/91.5% versus 32.5%/77.8%.

