$ALNYNeutralLow

PYOTT DAVID E I sold $274K of ALNY

PYOTT DAVID E I sold 921 shares of ALNYLAM PHARMACEUTICALS, INC. (ALNY) at $297.71 ($0.27M total) on 2026-06-01 under a Rule 10b5-1 trading plan.

6/10
3/10
Low
Neutral
SEC Form 4 filed June 3 for a June 1 sale
Neutral—insider selling on a 10b5-1 plan is usually not a catalyst

Insider selling under a pre-arranged 10b5-1 plan is typically low-signal for fundamentals, but can still influence near-term sentiment.

A director of Alnylam sold 921 shares in an open-market transaction disclosed via SEC Form 4 on June 1 under a 10b5-1 plan.

Likely limited/short-lived impact; any reaction should fade unless accompanied by other fundamental news.

Background

The article is an SEC Form 4 insider transaction disclosure for Alnylam Pharmaceuticals, Inc. (ALNY).

Why it matters

This provides a datapoint on director ownership but does not introduce new operational or clinical information.

Market relevance

Traders may briefly reassess sentiment around insider behavior, but the 10b5-1 structure and small size reduce expected fundamental impact.

Market effects

Minimal; this is company-specific insider activity without new biotech/clinical read-through.

None indicated.

None indicated.

Alternative perspectives

Even with 10b5-1, repeated or unusually large sales can be interpreted by some traders as confidence erosion—watch for follow-on filings.

The sale size is modest (921 shares) and the plan is pre-arranged, so the market may discount it; liquidity/positioning effects may matter more than fundamentals.

Key entities

  • ALNY

    Alnylam Pharmaceuticals, Inc.; subject of the insider transaction disclosure.

  • PYOTT DAVID E I

    Director who sold 921 shares in an open-market transaction under a 10b5-1 plan.

Related articles

$ALNYLowAI 8/10

JPMorgan Says Buy the Dip in These 2 Large-Cap Biotech Stocks

JPMorgan analyst Jessica Fye said large-cap biotech is at an “inflection point” as more firms convert pipeline wins into durable, profitable commercial franchises, with improving profitability and steady clinical catalysts. She highlighted Alnylam (ALNY) and Insmed (INSM) as “buy the dip” picks. For Alnylam, JPMorgan has an Overweight rating and a $420 price target; Q1 FY2026 revenue was $1.17B (+97% YoY).

$ALNYMedAI 9/10

Citi Initiates Alnylam (ALNY) With Buy Rating

Citi initiated coverage of Alnylam Pharmaceuticals (ALNY) on May 19 with a Buy rating and a $380 price target, citing strong performance from Amvuttra’s expanded ATTR-CM launch and saying recent pullbacks offer a long-term entry point. Citi noted competition concerns but expects more tailwinds than headwinds. Separately, Alnylam reported HELIOS-B Phase 3 results for vutrisiran, supporting first-line use in ATTR-CM.