Addex Therapeutics: Addex Announces Publication of Research Highlighting Therapeutic Potential of mGlu7 Modulation in Regulating Sleep and Wakefulness
Addex Therapeutics (SIX: ADXN, Nasdaq: ADXN) said preclinical research published in the International Journal of Neuropsychopharmacology shows its mGlu7 negative allosteric modulator ADX71743 alters sleep-wake regulation in rats, increasing wakefulness and reducing REM and non-REM sleep, and changes stress-related neurotransmitters. The company links results to the rationale for its mGlu7 program via Neurosterix.
How this was made
The 30-second read
Why it matters
The publication adds incremental evidence that mGlu7 modulation can regulate sleep-wake and stress-related neurochemistry, supporting the target mechanism for future development.
Market read
Traders may view the news as supportive for the mGlu7 thesis, but it is not a direct clinical or financial catalyst.
What to watch
The release emphasizes Neurosterix’s ongoing development but provides no new program milestones, timelines, or funding details that would change valuation expectations.
Background
Addex is a clinical-stage CNS biopharma developing allosteric modulators; ADX71743 is the mGlu7 NAM prototype and is part of the mGlu7 program advanced by Neurosterix.
Ticker impact
Addex says preclinical data in rats show ADX71743 (mGlu7 NAM) increases wakefulness and alters stress neurotransmitters, published today.
Likely modest, sentiment-driven reaction; limited follow-through unless paired with new clinical milestones.
The article is a research publication with animal-model endpoints and no disclosed advancement (e.g., IND/Phase start, dosing, trial results) or funding/partnership change.
Market effects
Reinforces investor interest in mGlu7 allosteric modulation for CNS indications (sleep/stress), but remains preclinical.
Could marginally support Swiss/Nasdaq-listed small-cap biotech sentiment, without broader sector read-through.
Limited global impact; preclinical animal data typically has narrow immediate market effect.
Counterpoint
Preclinical sleep/stress effects in rats may not translate to humans; without clinical-stage updates, the market may discount the news.
Key entities
- companyAddex Therapeutics
Clinical-stage biopharmaceutical company announcing publication of new preclinical mGlu7 NAM research.
- drug_candidateADX71743
Selective negative allosteric modulator of mGlu7; reported to modulate sleep-wake and stress neurotransmitters in rats.
- companyNeurosterix
Neuroscience company launched by Addex and Perceptive Advisors in 2024; advancing the mGlu7 program.



