Karyopharm Therapeutics (KPTI) Expected to Beat Earnings Estimates: What to Know Ahead of Q2 Release

Karyopharm Therapeutics Inc. (KPTI) shares fell about 68% after the company reported topline results from its Phase 3 XPORT-EC-042 trial. The trial did not meet its primary endpoint of progression-free survival. The stock dropped 68.17% to $2.2350 on Nasdaq from $7.01 prior close.

Karyopharm Therapeutics (KPTI) reported topline results from its Phase 3 XPORT-EC-042 trial of selinexor as maintenance therapy in TP53 wild-type advanced or recurrent endometrial cancer. The trial missed the primary endpoint for progression-free survival, though median PFS was 12.75 months vs 7.43 months with placebo in 236 patients. No new safety signals were reported; full data planned for a medical meeting.

Karyopharm Therapeutics shares fell about 67% to $2.29 after its Phase 3 XPORT-EC-042 endometrial cancer trial missed its primary goal, with no statistically significant progression-free survival improvement versus placebo. Analysts downgraded and cut price targets (e.g., Baird $15 to $3, H.C. Wainwright $13 to $3). Karyopharm said it will scale back endometrial plans and focus on myelofibrosis and multiple myeloma.

– Company Plans to Submit sNDA in August 2026 and Will Request Priority Review – – Following FDA Engagements, Company Plans to Submit sNDA under Accelerated Approval Based Upon Compelling SVR35 Data and Preliminary Overall Survival Data Observed at the Time of the Topline Results – – Company Plans to Use Long-Term Overall Survival Data from the Ongoing Phase 3 SENTRY Trial to Verify Clinical Benefit – – If Approved, Selinexor in Combination with Ruxolitinib has the Potential to Become the...

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