Instinct Bio secures Jakarta clinic site, sets subscription tiers

INSTINCT BIO TECHNICAL CO HOLDINGS INC. (BIOT) furnished an SEC Form 6-K — earnings release. Exhibit 99.3 Instinct Bio Returns to Profit and Grows Revenue Nearly 10% in Yen Terms in First Half of Fiscal 2026 TOKYO, October 16, 2026 -- Instinct Bio Technical Company Holdings Inc. (Nasdaq: BIOT) ("BIOT" or the "Company"), a Japan-based developer, manufacturer and seller of

Instinct Bio (BIOT) shares fell 51.46% to $1.33 Tuesday and dropped another 20.30% in after-hours to $1.06. The Nasdaq-listed biotech completed a business combination with Relativity Acquisition Corp. It entered an indicative term sheet for an equity purchase facility to sell up to $150M of common stock over three years, priced near VWAP less a discount, to fund development and working capital.

ORIC Pharmaceuticals reported Phase 1b data for enozertinib in 1L EGFR atypical NSCLC, showing 84% systemic and 70% intracranial ORR. The company plans to start the Phase 3 Redwood-1 trial in 1H 2027. According to ORIC, this marks a transition to late-stage development for enozertinib.

ORIC Pharmaceuticals reported preclinical data indicating its drug rinzimetostat may improve sensitivity to androgen receptor inhibition in prostate cancer, supporting its ongoing Phase 3 trial. The company believes this supports the drug's use across various disease settings.

ORIC Pharmaceuticals presented preclinical and translational data at ESMO Congress 2026, showing that rinzimetostat, its prostate cancer drug, enhances sensitivity to androgen receptor inhibition. The data suggest potential advantages over EZH2 inhibitors, including maintained effectiveness against resistance mutations and a favorable safety profile. ORIC's chief scientific officer highlighted the drug's potential best-in-class profile and its ongoing evaluation in the Himalayas-1 Phase 3 trial.

ORIC Pharmaceuticals presented data showing its lung cancer drug, enozertinib, shrank brain tumors in 70% of assessed patients with EGFR atypical mutations. The company plans to start a global Phase 3 trial in 1H 2027, with enrollment including patients with untreated brain metastases. Enozertinib showed a favorable safety profile and meaningful systemic and intracranial antitumor activity.