New Phase 3b data show Lilly's EBGLYSS (lebrikizumab-lbkz) delivered significant and rapid improvements in skin clearance, itch, pain, and patient satisfaction in people with moderate-to-severe hand and foot atopic dermatitis

Eli Lilly's phase 3 TRIUMPH-2 study shows retatrutide, a triple hormonal agonist, achieved significant weight loss (up to 20.8%) and glycemic improvements in adults with type 2 diabetes (T2D) and obesity. The study, presented at EASD 2026, involved 1152 participants and showed retatrutide's efficacy estimand exceeded 20% weight reduction, a threshold not previously reached in T2D patients.

Eli Lilly (LLY) reported positive Phase 3 trial results for Foundayo, showing cardiovascular benefits in type 2 diabetes patients. The drug matched insulin glargine in preventing major adverse cardiovascular events while improving A1C levels and weight reduction. Foundayo reduced serious cardiovascular risks by 16%, cardiovascular mortality by 53%, and overall mortality by 57%.

Eli Lilly's oral GLP-1 drug, Foundayo (orforglipron), showed cardiovascular safety and sustained A1C reduction in the ACHIEVE-4 trial. Participants had a 16% lower risk of MACE-4 and 23% lower risk of MACE-3 vs. insulin glargine. Foundayo also demonstrated weight loss and improved cardiovascular risk factors. The trial involved 2,749 adults with type 2 diabetes and obesity or overweight.

Eli Lilly presented Phase 3 data for retatrutide, showing 23% weight loss and significant blood sugar reductions. Novo Nordisk and Genentech licensed weight-loss molecules from Jiangsu Hengrui and Hanmi Pharmaceuticals, respectively, for upfront payments of $300M and $190M. Roche abandoned its obesity drug, emugrobart, after Phase 2 trial failures.

Eli Lilly's Foundayo (orforglipron) showed a 16% lower risk of major cardiovascular events and 23% lower risk of cardiovascular death, heart attack, or stroke compared to insulin glargine in the ACHIEVE-4 trial. The drug also demonstrated improvements in A1C, weight, and other cardiometabolic health measures. Lilly plans to present these results at the EASD meeting and publish them in The Lancet.

Eli Lilly's experimental weight-loss drug retatrutide showed significant results in trials, with participants losing up to 60-70 pounds. The drug also improved blood-sugar levels, with some diabetes patients achieving remission. The company plans to seek FDA approval next year, according to trial results published in the Lancet and the New England Journal of Medicine.