ArriVent Announces Program Update from the Phase 3 FURVENT Trial of Firmonertinib in First-Line EGFR Exon 20 Insertion Mutant NSCLC

ArriVent BioPharma's lung cancer drug, furmonertinib, failed to meet its main goal in a late-stage study, missing a key benchmark in tumor progression. The company's shares fell over 50% in pre-market trading. CEO Bing Yao stated the company will review the data to determine next steps. The drug is approved in China for certain lung cancers, but the study's failure may limit its market potential.

ArriVent BioPharma (AVBP) shares fell over 50% after announcing its lead drug, firmonertinib, failed a late-stage lung cancer trial. The company stated the oral therapy did not meet its primary endpoint.

Arrivent Biopharma (AVBP) shares dropped 56.7% in pre-market trading after its Phase 3 FURVENT trial failed to meet the primary endpoint of progression-free survival for firmonertinib. The 240mg dose showed a median PFS of 11.0 months vs. 9.5 months for chemotherapy, but the hazard ratio was not statistically significant. CEO Bing Yao noted the disappointing results and the company is evaluating next steps.

ArriVent BioPharma's (AVBP) stock dropped 63% after its Phase 3 FURVENT trial for firmonertinib failed to meet the primary endpoint of progression-free survival in NSCLC patients. The trial compared two doses of firmonertinib against chemotherapy, with neither dose achieving statistical significance. Secondary endpoints showed some clinical benefit, but the company expressed disappointment in the results. The trial enrolled 398 patients globally.

ArriVent's Phase 3 FURVENT trial of firmonertinib missed the primary PFS endpoint by BICR (p=0.0654). The 240mg arm showed median PFS of 11.0 months vs. 9.5 months for control. Investigator-assessed PFS favored 240mg (11.1 vs. 7.1 months). Confirmed ORR by BICR was 60% for 240mg, 35% for 160mg, and 33% for control. Safety data were consistent with prior studies.

ArriVent BioPharma, Inc. (AVBP) filed an SEC Form 8-K — Results of Operations and Financial Condition. Exhibit 99.1 ArriVent BioPharma Reports Second Quarter 2026 Financial Results · Topline global pivotal Phase 3 data for firmonertinib in first-line EGFR exon 20 insertion mutant NSCLC expected 2H 2026 · ARR-217, a CDH17 targeted ADC for gastrointestinal malignancies, advanced to