Eli Lilly And Company Announces New Exploratory Phase 3b Data On Taltz And Zepbound In Adults With Psoriasis And Obesity
Eli Lilly presented data from the TOGETHER-PsO Phase 3b trial showing that combining Taltz (ixekizumab) and Zepbound (tirzepatide) led to broader biomarker responses in adults with psoriasis and obesity compared to Taltz alone. The trial, presented at the 2026 Fall Clinical Dermatology Conference, found greater reductions in inflammatory immune activity with the combination treatment.
How this was made
The 30-second read
Why it matters
The trial shows broader biomarker changes and improved skin clearance, indicating a possible new indication for the drug combo.
Market read
New trial data could influence Lilly's pipeline valuation and affect biotech sector sentiment.
What to watch
Potential safety concerns of combined therapy and competition from other obesity‑psoriasis pipelines.
Background
The TOGETHER-PsO Phase 3b trial evaluated Taltz (ixekizumab) with Zepbound (tirzepatide) versus Taltz alone in adults with moderate‑to‑severe plaque psoriasis and obesity.
Ticker impact
Eli Lilly disclosed new exploratory Phase 3b data on the combined use of Taltz and Zepbound in psoriasis patients with obesity.
likely upward pressure as investors price in potential label expansion
Early trial data showing broader biomarker response and improved PASI outcomes suggest commercial potential, but further confirmatory data are needed.
Market effects
could lift other biotech firms developing obesity‑psoriasis combos
U.S. biotech sector may see modest gains
limited to investors tracking Lilly and related therapeutic areas
Counterpoint
Data are exploratory; investors may wait for Phase 3 confirmatory results before acting.
Key entities
- companyEli Lilly and Company
Pharmaceutical company conducting the trial.
- drugTaltz
Ixekizumab, used for psoriasis.
- drugZepbound
Tirzepatide, approved for obesity and sleep apnea.


