Merck KGaA to Spend $1.3bn on Silence Therapeutics
Merck KGaA (down 0.83% at EUR143.10) agreed to acquire Silence Therapeutics for $1.3bn, or $20 per ADS, an 82% premium. The deal, financed via debt, aims to bolster Merck's rare disease portfolio, including Divesiran for polycythemia vera. It is expected to close in Q1 2027, pending approvals. Silence's enterprise value is $1.1bn. Merck also plans to present oncology data at ESMO 2026.
How this was made
The 30-second read
Why it matters
The acquisition expands Merck's rare‑disease portfolio and introduces a late‑stage siRNA candidate, Divesiran, potentially enhancing long‑term growth.
Market read
A material M&A deal in the pharma sector with immediate pricing impact and strategic implications.
What to watch
Regulatory approval risk for the acquisition and integration of siRNA platform.
Background
Merck KGaA announced a definitive agreement to acquire Silence Therapeutics for $1.3bn, financing the deal with new debt.
Market effects
strengthens Merck's rare‑disease pipeline, may spur M&A activity in siRNA therapeutics.
European biotech sector could see increased investor interest.
large‑cap pharma M&A adds to overall market activity.
Counterpoint
Merck's cash outlay could strain balance sheet, prompting a short‑term sell‑off.
Key entities
- CompanyMerck KGaA
German pharmaceutical and chemicals group executing the acquisition.
- CompanySilence Therapeutics
British biotech developing siRNA therapies, target of the acquisition.


