Nearly 4 in 10 patients on a cancer drug combination were alive at three years.

Jazz Pharmaceuticals (JAZZ) reported positive Phase 3 trial results for Ziihera in combination with chemotherapy, showing a 24% reduction in death risk versus trastuzumab. The trial, conducted with BeOne Medicines, found nearly 40% of patients alive at three years with a median overall survival of 27 months. JAZZ shares were down 1.11% on the Nasdaq.

Jazz Pharmaceuticals (JAZZ) presented Phase 3 trial results showing its drug Ziihera, combined with chemotherapy, extended survival in HER2-positive stomach cancer patients. The trial reported a median overall survival of 27.0 months for the Ziihera combination, compared to 19.6 months for the standard treatment. The FDA approved two Ziihera-containing regimens in August 2026. The trial involved 914 patients across 225 sites in over 30 countries.

Jazz Pharmaceuticals (JAZZ) reported updated results from the Phase 3 HERIZON-GEA-01 trial, showing Ziihera® (zanidatamab-hrii) combinations improved overall survival in HER2+ advanced gastroesophageal adenocarcinoma. Key findings: 39.8% of patients alive at three years with Ziihera plus tislelizumab and chemotherapy, median OS of 27.0 months. Ziihera plus chemotherapy reduced death risk by 24% vs. trastuzumab. Results presented at ESMO 2026.

Jazz Pharmaceuticals reported Phase 3 trial results showing Ziihera plus chemotherapy reduced death risk by 24% vs. trastuzumab plus chemo, with 40% survival at three years for Ziihera+tislelizumab+chemo. The data supports FDA-approved first-line use. Investors should monitor adoption, sales, and potential label expansions.

Jazz Pharmaceuticals announced that Samantha Pearce, its Executive Vice President and Chief Commercial Officer, will retire. Her departure is effective upon the appointment of a successor or by June 30, 2027, according to the company. The board will consider both internal and external candidates for the role.

Citigroup initiated coverage on Nuvation Bio (NUVB) and Jazz Pharmaceuticals (JAZZ) with Buy ratings. NUVB received a $12 price target, citing strong sales of Ibtrozi and potential of safusidenib. JAZZ was given a $320 target, highlighting Ziihera's growth potential. Both stocks are seen as covered call opportunities.