New Personalised mRNA Therapy Improves Melanoma Outcomes: ESMO 2026

Merck and Moderna's Phase 3 trial showed a 42% reduction in melanoma recurrence or death risk when combining their mRNA vaccine with Keytruda. The trial involved 1,137 patients with high-risk melanoma. Overall survival data is pending. The vaccine is not yet approved, and commercial success is uncertain. Moderna aims for approval in 2025.

Moderna and Merck's personalized mRNA cancer vaccine, combined with pembrolizumab, reduced melanoma recurrence or death risk by 42% in a Phase III trial with 1,137 patients. After two years, 82.2% of vaccine group patients were alive without recurrence, versus 70.0% with pembrolizumab alone. The vaccine targets individual tumor mutations, showing broader applicability in high-risk melanoma.

Moderna's stock fell over 1% after Phase 3 melanoma vaccine trial data showed a 42% reduction in recurrence or death risk. Analysts had mixed reactions, with price targets ranging from $80 to $137. The trial, conducted with Merck, involved 1,137 participants and reported side effects like fever and fatigue. Full data will be presented at a cancer conference in Madrid.

Moderna and Merck's Phase 3 trial of personalized melanoma vaccine intismeran autogene with Keytruda showed a 42% reduction in recurrence or death risk vs. Keytruda alone. Two-year recurrence-free survival was 82.2% for the combination vs. 70.0% for Keytruda alone. The combination had more adverse events. Specialists called results clinically meaningful but not yet establishing longer life. Moderna shares fell 17.57% following the release.

Moderna (MRNA) reported Phase 3 results showing its melanoma combo vaccine with Keytruda reduced recurrence/death risk by ~42% and distant metastasis by ~38%. The EU and FDA approved other Moderna vaccines. Analysts had mixed reactions: Citi reiterated a Sell rating, Bernstein maintained Market Perform with a $45 target, and TD Cowen kept Hold with a $90 target. MRNA stock showed volatility.

Moderna (MRNA) and Merck reported a 42% reduction in melanoma recurrence or death in a Phase 3 trial of Moderna's cancer vaccine. Shares fell 17.6% after data leaked early. The trial tested intismeran autogene with Merck's Keytruda. Moderna reported Q2 2026 loss of $782m on $145m revenue.