AMGN: DeLLphi-305 showed a significant survival benefit for first-line maintenance IMDELLTRA plus IMFINZI

Amgen's Imdelltra combined with AstraZeneca's Imfinzi showed a 58% reduction in death risk for extensive-stage small cell lung cancer patients, increasing median survival to 21.1 months. The study, presented at the European Society for Medical Oncology Congress, suggests potential for Imdelltra as a first-line maintenance therapy. Imdelltra reported $288M in Q2 2023 sales and $627M in 2025 global sales.

Amgen's Phase III trial showed that IMDELLTRA plus IMFINZI reduced death risk by 58% vs. IMFINZI alone in extensive-stage small-cell lung cancer, with a hazard ratio of 0.42. The combo also improved progression-free survival and response rates. Amgen plans global regulatory submissions and further studies. According to the company, adverse events were manageable.

Amgen announced that a Phase 3 trial of its drug Imdelltra combined with AstraZeneca's Imfinzi showed a 58% reduction in death risk for extensive-stage small cell lung cancer patients. Median overall survival increased to 21.1 months compared to 12.7 months for Imfinzi alone. Amgen plans to share these findings with global regulators.

Amgen's Imdeltra combined with AstraZeneca's Imfinzi reduced death risk by 58% in late-stage small-cell lung cancer trials. Median survival increased from 12.7 to 21.1 months. Amgen and AstraZeneca are involved in the study, which may change treatment standards.

Amgen announced that adding IMDELLTRA to IMFINZI reduced the hazard of death by 58% in a Phase 3 lung-cancer trial. The company's stock closed at $439.26 on Friday, trading at 19.2 times its adjusted earnings midpoint of $22.90. A 10% share-price gain would require roughly $1.25 billion more in annual adjusted net income, according to TECHi's calculations.

Amgen reported that adding tarlatamab to durvalumab reduced the hazard of death by 58% in a Phase 3 lung cancer trial. Median overall survival was 21.1 months with the combination vs. 12.7 months with durvalumab alone. The company plans to share findings with regulators.