AstraZeneca's Imfinzi Combo Therapy Reduces Death Risk in Late-stage Small Cell Lung Cancer Trial

AstraZeneca announced positive results from a Phase III study of its combination treatment for bladder cancer. The study met its primary endpoint, showing improved outcomes. The company's shares have seen a 3.04% increase year-to-date, despite a recent 1.20% decline. The news could impact investor sentiment and trading activity.

A Phase 3 trial of a combination treatment for advanced lung cancer by Amgen and AstraZeneca showed a 58% reduction in death risk, according to the companies.

Amgen's Imdelltra combined with AstraZeneca's Imfinzi showed a 58% reduction in death risk for extensive-stage small cell lung cancer patients, increasing median survival to 21.1 months. The study, presented at the European Society for Medical Oncology Congress, suggests potential for Imdelltra as a first-line maintenance therapy. Imdelltra reported $288M in Q2 2023 sales and $627M in 2025 global sales.

Amgen reported that a combination of its drug Imdelltra and AstraZeneca’s Imfinzi reduced death risk by 58% in a late-stage lung cancer trial. Median survival was 21.1 months for the combo group vs. 12.7 months for Imfinzi alone. Amgen's chief medical officer called the data potentially practice-changing. Imdelltra sales grew 115% year-over-year to $288M in Q2.

Amgen's Imdeltra combined with AstraZeneca's Imfinzi reduced death risk by 58% in late-stage small-cell lung cancer trials. Median survival increased from 12.7 to 21.1 months. Amgen and AstraZeneca are involved in the study, which may change treatment standards.

A Phase 3 trial found that a combination of tarlatamab (Amgen) and durvalumab (AstraZeneca) reduced death risk by 58% and extended median survival to 21.1 months in extensive-stage small cell lung cancer patients. The study involved 563 patients across 29 countries. Amgen plans regulatory submissions.