2026 ESMO | Innovent Presented Phase 1 Study Data for IBI3001, a First-in-Class EGFR/B7H3 Bispecific ADC

Innovent Biologics presented Phase 2 data for IBI354, a HER2-targeted ADC, at the 2026 ESMO Congress. The drug, combined with pertuzumab, showed a 95% objective response rate and favorable safety in first-line HER2-positive breast cancer. Innovent has initiated Phase 3 trials for IBI354 and plans further studies. The company aims to expand its ADC pipeline and improve cancer treatments.

Innovent Biologics (IVBXF) reported that its Phase 3 G-HOPE-001 study of arcotatug tavatecan met primary endpoints of overall survival (10.2 months vs. 6.9 months) and progression-free survival (7.1 months vs. 3.1 months) in CLDN18.2-positive advanced gastric cancer. The data were presented at the 2026 ESMO Congress. The stock closed at $12.21, up 0.15% on October 21.

Innovent Biologics (HKEX: 01801) announced positive Phase 3 results for arcotatug tavatecan in CLDN18.2-positive gastric cancer, meeting primary endpoints of overall survival (OS) and progression-free survival (PFS). The study showed median OS of 10.2 months vs. 6.9 months for the control group, and median PFS of 7.1 months vs. 3.1 months. The drug demonstrated a favorable safety profile. Innovent collaborates with Takeda for global development outside Greater China.

Innovent Biologics reported that its Phase 3 RESTORE-3 study of SYCUME (teprotumumab N01 injection) met primary endpoints in Chinese patients with inactive thyroid eye disease, showing significant reduction in eye protrusion and a favorable safety profile. The study involved 116 patients and achieved a 60.4% response rate. SYCUME is approved in China and added to the National Reimbursement Drug List in January 2026. The company's stock, 1801.HK, is currently trading at HKD 90.35, down 2.43%.

Innovent Biologics (1801.HK) announced that its Phase 3 RESTORE-3 study for SYCUME (teprotumumab N01 Injection) met primary endpoints in inactive thyroid eye disease, showing a 60.4% response rate and 1.88 mm reduction in eye protrusion. The drug is the first of its kind approved in China and the second globally. 1801.HK shares are down 2.43% at $90.35.

Innovent Biologics (HKEX: 01801) announced that its drug SYCUME® (Teprotumumab N01 Injection) met its primary endpoint in a Phase 3 trial for inactive thyroid eye disease (TED). The study showed a 60.4% response rate and a -1.88 mm reduction in proptosis at Week 24, with a favorable safety profile. SYCUME® is the first IGF-1R antibody drug in China and the second approved worldwide, included in China's National Reimbursement Drug List.