Innate Pharma S.A. (IPH) Shifts PACIFIC-9 Readout to H1 2027

Innate Pharma (IPH, IPHA) announced AstraZeneca (AZN) delayed the PACIFIC-9 trial data to H1 2027 from H2 2026, citing the study's event-driven nature. The trial tests durvalumab with monalizumab or oleclumab in Stage III lung cancer. Monalizumab is co-developed by Innate and AZN. Innate Pharma is a clinical-stage biotech listed in Paris and on Nasdaq.

AstraZeneca's PACIFIC-9 Phase 3 trial, evaluating durvalumab with monalizumab or oleclumab for unresectable Stage III NSCLC, has completed enrollment. Results are now expected in the first half of 2027, delayed from the second half of 2026. Monalizumab is developed by Innate Pharma in collaboration with AstraZeneca.

Innate Pharma (IPHA) reported Q2 2026 earnings, highlighting a cash position of -€21.4M, a $75M upfront payment from Sobi, and -€28M in net equity proceeds. H1 2026 net loss was -€19.6M, with revenue of -€5.7M. The company extended its cash runway to Q1 2028 and anticipates key milestones, including a Phase 3 readout for monalizumab and initial data for IPH4502. Management expects to file for accelerated approval of lacutamab in Sezary Syndrome in H2 2027.

Innate Pharma reported its first half 2026 results, highlighting a strategic partnership with Sobi for lacutamab, a $75M upfront payment, and a €30M equity financing. Key milestones include the initiation of the TELLOMAK-3 Phase 3 trial for lacutamab, expected to report data in Q1 2027, and the presentation of IPH4502 Phase 1 data at ENA 2026. The company also anticipates a PACIFIC-9 Phase 3 readout for monalizumab by year-end. As of June 30, 2026, Innate Pharma had a cash position of €21.4M and

Swedish Orphan Biovitrum AB (Sobi) and Innate Pharma (IPH, IPHA) announced their strategic partnership is now effective. Sobi will pay Innate $75 million upfront, with potential milestone payments up to $465 million. Innate will conduct a Phase 3 trial for lacutamab, a treatment for cutaneous T-cell lymphoma, with Sobi receiving exclusive commercialization rights.

Innate Pharma (NASDAQ:IPHA) completed enrollment in the dose-escalation portion of its Phase I trial of IPH4502, enrolling 76 patients by July 21. The company expects 10 to 15 patients at go-forward doses across post-PADCEV urothelial cancer, head and neck cancer, and NSCLC, with dose-escalation data later in 2024. Innate also awaits primary-endpoint data from AstraZeneca’s PACIFIC-9 monalizumab study by year-end, after a €30M financing extending its cash runway into 2028.