$ALNY

Barclays maintains Alnylam Pharmaceuticals at Overweight, lowers price target to $380 from $450

Barclays kept Alnylam Pharmaceuticals at Overweight, cutting its price target to $380 from $450, a 15.6% reduction. This implies a 158.2% upside from the Oct 30 close of $147.17. Recent analyst targets for the company range from $199 to $354.

Original reporting
Published Nov 2, 2026, 8:05 PM UTC
Analysis
AlphAI AI DeskAI-generated
Added to AlphAI Nov 2, 2026, 8:08 PM UTC. Informational, not investment advice.
How this was made
AlphAI summarizes source reporting and applies a structured AI analysis for relevance, timing, sentiment and ticker impact. Always verify material claims with the original publisher.
Barclays maintains Alnylam Pharmaceuticals at Overweight, lowers price target to $380 from $450 — source image
Decision brief

The 30-second read

$ALNYBearishLow
01

Why it matters

The downgrade may prompt short-term selling pressure but does not indicate a fundamental shift in the company's business.

02

Market read

A modest analyst target cut for ALNY, likely causing limited price movement.

03

What to watch

Potential pipeline milestones or partnership news not covered in the article could offset the target reduction.

Relevance 5/10Novelty 4/10Timing: today

Background

Barclays' analyst team adjusted its valuation for Alnylam Pharmaceuticals, reflecting a more conservative outlook.

Company-level read

Ticker impact

$ALNYBearishMedium confidence
Context

Barclays lowered its price target on Alnylam Pharmaceuticals to $380 from $450, a new analyst rating change.

Expected impact

likely downward pressure as investors reassess valuation

Evidence & confidence

Target reduction is a fresh analyst action, but the magnitude is modest and does not involve material corporate events.

Market effects

May slightly temper sentiment in the biotech sector.

Limited to U.S. biotech investors.

Minimal global impact.

Counterpoint

The target cut could be an overreaction; the stock may still have upside if upcoming trial data are positive.

Key entities

  • Barclays

    Equity research firm providing the price target revision.

  • Alnylam Pharmaceuticals

    Biotech firm developing RNAi therapeutics.

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