TD Cowen maintains Krystal Biotech at Buy, lowers price target to $380 from $403

TD Cowen kept its Buy rating on Krystal Biotech but reduced its price target to $380 from $403, a 5.7% decrease. The new target suggests a 28.4% upside from the Nov 2 close of $295.90, according to the firm.

Original reporting
Published Nov 3, 2026, 3:45 PM UTC
Analysis
AlphAI AI DeskAI-generated
Added to AlphAI Nov 3, 2026, 3:50 PM UTC. Informational, not investment advice.
How this was made
AlphAI summarizes source reporting and applies a structured AI analysis for relevance, timing, sentiment and ticker impact. Always verify material claims with the original publisher.
TD Cowen maintains Krystal Biotech at Buy, lowers price target to $380 from $403 — source image
Decision brief

The 30-second read

$KRYSNeutralLow
01

Why it matters

A lower price target can influence positioning and expectations, but the unchanged Buy rating suggests the core thesis remains supportive.

02

Market read

Valuation expectations for KRYS are adjusted downward by TD Cowen, with limited immediate catalyst beyond the PT change.

03

What to watch

Without the underlying rationale for the PT change, traders may overreact to the number versus the unchanged recommendation.

Relevance 4/10Novelty 4/10Timing: today (analyst price-target update)

Background

The piece is an analyst note summary from TD Cowen, not a company disclosure.

Company-level read

Ticker impact

$KRYSNeutralMedium confidence
Context

TD Cowen maintained Krystal Biotech at Buy but cut its price target to $380 from $403, signaling a valuation reset despite the unchanged rating.

Expected impact

Likely mild downside bias as traders price in the lower target, while the unchanged Buy rating limits downside follow-through.

Evidence & confidence

The article provides a specific, same-day analyst price-target cut with no new operational or clinical catalyst described.

Market effects

Limited read-through to biotech peers because this is a single-name valuation adjustment without new trial or regulatory data.

No clear regional spillover implied.

No global market linkage indicated.

Counterpoint

The unchanged Buy rating may matter more than the PT cut, suggesting the downgrade is incremental rather than a thesis break.

Key entities

  • Krystal Biotech

    Subject of the analyst action: maintained Buy, lowered price target to $380 from $403.

Related articles

Med

Krystal Biotech, Inc. Q3 2026 Earnings Call Summary

Krystal Biotech reported 30% YOY revenue growth for VYJUVEK, driven by expanding prescriber base and international launches. Gross margin was 94%, slightly decreased due to international markets. The company announced a $400M share repurchase program and expects international revenue to scale with upcoming launches. Clinical milestones include data readouts and FDA discussions for Gorlin syndrome and Ocular DEB programs. Management revised R&D and SG&A guidance downward to $155M-$165M.

$KRYSMed

Krystal Biotech Q3 Earnings Call Highlights

Krystal Biotech reported Q3 revenue of $32M for VYJUVEK. Expansion in Europe includes pricing deals in Germany, Japan, and Italy, with launches expected in early 2027. Pipeline updates include promising data for KB113 in Gorlin syndrome and delays in other programs. Q3 gross margin was 94%, with adjusted expense guidance lowered to $155M-$165M. The board approved a $400M share buyback program.