Sangamo (SGMO) Q3 2025 Earnings Call Transcript

Cumberland Pharmaceuticals (CPIX) reported Phase 2a trial results for ifetroban in systemic sclerosis, showing safety and tolerability but no efficacy conclusions. Shares fell 17.55% in after-hours trading. The 12-month trial enrolled 41 patients, with most experiencing limited disease progression. Cumberland plans further studies to guide future development.

Amazon and Google signed 20-year deals with Constellation Energy for nuclear power, totaling $4.3B. Amazon secured 690 MW from Calvert Cliffs, while Google's deal covers 11 reactors. Critics question if these agreements will meet data center demand and impact household electricity costs. The Energy Department approved $4.4B in loans for nuclear facilities. Meta, Microsoft, and Amazon have also made significant nuclear power agreements.

Boeing (NYSE:BA) halted 777 freighter production for two months due to a supplier dispute with Vaero, costing up to $6.5M daily. The issue also impacted 767 aircraft production. Boeing is bringing manufacturing in-house and has removed two partially assembled 777 freighters from its assembly line. The 777X program is unaffected. Boeing has delivered 21 777 freighters this year, with more possible by 2026.

Moderna and Merck reported late-stage trial results showing their personalized mRNA melanoma vaccine, intismeran, reduced relapse risk by 42% when combined with Keytruda. The trial involved 1,137 patients, with 82% of vaccine recipients showing no recurrence after two years, compared to 70% for the placebo group. The companies plan to present the findings at a medical conference and continue long-term studies.

Allegiant Travel Co. converted 6 Boeing 737 MAX 8 options into firm orders, totaling 56 firm aircraft with 74 remaining options. The deal, valued at over $720M, extends deliveries to 2028. The company also disclosed new executive contracts through 2029, including CEO Gregory Anderson's $750K base salary and performance-based compensation.

Helen Chiang, Xbox's COO, left Microsoft after three months. She had led Minecraft and was promoted in July. Xbox CEO Asha Sharma thanked her but gave no reason. Chiang's responsibilities will be split among other leaders. Microsoft plans 3,200 job cuts by 2027, with more layoffs expected this year and next.