Cellectis Reports Third-Quarter 2026 Results and In Vivo Editing Data

Cellectis (CLLS) reported Q3 earnings, highlighting HEAL-201's potential in reducing PCSK9 levels and plans for a Phase 1 trial. The company expects to cut global headcount by up to 70% in 2026-2027. Revenues fell to $19.9M from $67.4M YoY, while R&D expenses rose to $108.8M. Cash reserves were $149M as of Sept. 30, down from $211M at the end of 2025.

Cellectis reported a $101.1M net loss for the nine months ended September 30, 2026, up from $41.3M in 2025, with $149M in cash and deposits. The company expects funding to last into the second half of 2028. This follows a strategic shift to in vivo gene editing and restructuring.

Cellectis (ALCLS) shared expanded preclinical data for its APOC3 base editor, .HEAL-101, and announced plans to initiate a Phase 1 investigator-initiated trial in China, with preliminary data expected in the second half of 2027.

Cellectis (Nasdaq: CLLS) presented preclinical data for its .HEAL-101 gene therapy, showing 70% in vivo editing of human APOC3 and 76% triglyceride reduction in mice. The company plans a Phase 1 trial in China, with preliminary data expected in 2027. Cellectis aims to develop a one-time treatment for severe hypertriglyceridemia.

Cellectis SA (CLLS) shares dropped 14.6% after Barclays downgraded the stock to Underweight, cutting its price target to $1.30 from $9.00. Analyst Lukas Shumway cited lack of conviction in Cellectis' new programs, assigning negative net present values to .HEAL-101 and .HEAL-201. The valuation model now includes $2 each for Royalties and Milestones, -$1 for Debt, and $5 for Cash, assuming a capital raise in late 2027.

Cellectis (CLLS) reported Q2 2026 cash, cash equivalents and fixed-term deposits of $169M as of June 30, 2026, versus $145M in Q2 2025, citing runway into Q4 2027. At EHA 2026, lasme-cel in BALLI-01 moved to pivotal Phase 2 after FDA RMAT (June 2026), with ORR 67% and CR 56% in Phase 1. Eti-cel in NATHALI-01 showed ORR 46% and CR 31%.