Ultragenyx reaffirms 2027 profitability goal after cutting GTX‑102 and cutting workforce

Ultragenyx Pharmaceutical announced it will pursue GAAP profitability by 2027, targeting R&D spending below $350 million and SG&A below $375 million. The company discontinued its GTX‑102 program, ended two clinical studies and will reduce its workforce by about 20%. It also reported FDA approval of two drugs and reiterated its 2027 profit target.

The cost‑reduction plan and profit target could improve margins and support higher valuations, as reflected by an average 12‑month price target of $26.40 from analysts. The workforce cut and program shutdown may affect short‑term execution risk.

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