Moderna shares plunge after leaked melanoma vaccine data shows 42% risk reduction

Moderna's stock fell about 17% after an early leak of Phase 3 results for its melanoma vaccine, which showed a 42% cut in cancer recurrence or death when used with Merck's Keytruda. The premature release erased roughly $18‑$20 billion of market value. Merck confirmed the data had been released ahead of schedule and saw its own share price dip before recovering. Full trial data are expected at a European cancer conference in Madrid on Saturday.

The sharp price drop reduces Moderna's market capitalization by up to $20 billion, affecting shareholders and potentially altering the valuation of its oncology pipeline. Merck's brief share decline and subsequent rebound indicate market sensitivity to the joint vaccine's perceived efficacy.

  • 1Moderna shares fell 17% after the leak.
  • 2The leak removed between $18 billion and $20 billion of market value.
  • 3The trial showed a 42% reduction in recurrence or death risk when combined with Merck's Keytruda.
  • 4Merck confirmed the data were released early.
  • 5Full trial results are scheduled for release on Saturday at a cancer conference in Madrid.

Sources