Exelixis beats Q3 estimates and maintains 2026 revenue guidance

Exelixis reported third-quarter 2026 revenue of $658.7 million on October 29, with GAAP diluted EPS of $0.85 and non-GAAP diluted EPS of $0.94. Cabozantinib net product revenue reached $604.9 million, while the company maintained 2026 total revenue guidance of $2.5B-$2.55B. Exelixis said it expects topline results from the phase 3 STELLAR-304 trial in the first quarter of 2027 and has seven potentially label-enabling zanzalintinib studies underway.

The results reinforce CABOMETYX as Exelixis' current revenue base while the company funds zanzalintinib development. The maintained revenue outlook and upcoming 2027 trial data create near-term milestones for investors, although the stock edged lower after the report according to one material.

  • 1Third-quarter 2026 total revenue was $658.7 million, up 10% year over year.
  • 2Third-quarter GAAP net income was $218.1 million and GAAP diluted EPS was $0.85.
  • 3Third-quarter non-GAAP diluted EPS was $0.94.
  • 4Cabozantinib net product revenue was $604.9 million in the quarter.
  • 5Exelixis set 2026 total revenue guidance at $2.5B-$2.55B.
  • 6The company expects topline STELLAR-304 results in the first quarter of 2027.
  • Material 4 describes $0.85 GAAP EPS as beating an estimate of 89 cents, while other materials describe $0.94 non-GAAP EPS as the estimate-beating result; the estimate basis is not clearly identified.

Sources