Ultragenyx posts Q3 loss, announces expense cuts and reaffirms 2026 revenue guidance

Ultragenyx Pharmaceutical reported third‑quarter 2026 revenue of $173 million and a net loss of $118 million, or $1.16 per share. The company received FDA approvals for its gene therapies GENGLYCOS and FAYUVI and sold the associated priority‑review vouchers for a combined $413 million. It announced a roughly 20% headcount reduction and said the cuts will help achieve profitability in 2027 while reaffirming its full‑year 2026 revenue outlook of $730 million‑$760 million.

The company expects the expense reductions and PRV proceeds to drive a transition to GAAP profitability in 2027. Reaffirmed revenue guidance signals that the new product launches will not be needed to meet the 2026 target, reducing upside risk for investors.

  • 1Total revenue in the third quarter 2026 was $173 million.
  • 2Net loss for the quarter was $118 million, or $1.16 per share basic and diluted.
  • 3The FDA approved two gene‑therapy BLAs, GENGLYCOS and FAYUVI, in the quarter.
  • 4Two priority‑review vouchers were sold for a combined price of $413 million, with net proceeds expected to be about $350 million.
  • 5Ultragenyx is reducing headcount by approximately 20%, to a workforce of roughly 1,000 employees.
  • 6The company reaffirmed its full‑year 2026 revenue guidance of $730 million‑$760 million, excluding revenue from the new launches.

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