Insmed raises 2026 revenue guidance after strong third-quarter results

Insmed reported third-quarter 2026 revenue of $524.4M, up 268% year over year, with a net loss of $100.3M. BRINSUPRI generated $400.1M and ARIKAYCE generated $124.4M during the quarter. Insmed raised full-year 2026 revenue guidance for BRINSUPRI to $1.35B-$1.4B and for ARIKAYCE to $460M-$470M.

The higher guidance raises the company’s expected 2026 product revenue outlook, while the reported net loss shows Insmed remains unprofitable. Insmed expects to reach cash-flow positivity in 2027, according to the company’s earnings-call update.

  • 1Third-quarter 2026 revenue was $524.4M, up 268% year over year, and net loss was $100.3M.
  • 2BRINSUPRI generated $400.1M in third-quarter revenue and ARIKAYCE generated $124.4M.
  • 3Insmed raised 2026 BRINSUPRI revenue guidance to $1.35B-$1.4B and ARIKAYCE guidance to $460M-$470M.
  • 4The company received FDA priority review for ARIKAYCE’s supplemental application, with a target action date of Jan. 28, 2027.
  • Material 5 reports quarterly revenue of $425.5M, compared with $524.4M reported by the other earnings materials for the same quarter.
  • Material 5 reports prior or alternative 2026 guidance of $1.25B-$1.4B for BRINSUPRI and $450M-$470M for ARIKAYCE, differing from the raised ranges reported elsewhere.

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