Moderna reports positive Phase 3 results for its personalized melanoma vaccine with Merck’s Keytruda

Moderna announced that its personalized cancer vaccine, intismeran autogene, met recurrence‑free survival goals in a Phase 3 trial for melanoma when combined with Merck’s Keytruda. The company is now preparing an FDA submission with Merck. The news has driven the stock up about 600% this year, pushing the share price to roughly $242 and a market value near $96 billion.

The trial success has sparked strong investor enthusiasm, lifting Moderna’s share price far above the average analyst price target of $123, but the personalized nature of the product may limit rapid revenue growth. Analysts note that the company’s recent revenue of $1.94 billion and net loss of $2.82 billion highlight the financial risk of the oncology pivot.

  • 1Moderna’s personalized cancer vaccine intismeran autogene achieved positive Phase 3 results for melanoma in combination with Merck’s Keytruda, meeting recurrence‑free survival goals.
  • 2Moderna and Merck are moving toward preparing an FDA submission following the trial results.
  • 3Moderna’s stock has risen about 600% this year, trading around $242 per share as of October 20, 2026.
  • 4The company’s market capitalization is roughly $96 billion.
  • 5Average analyst price target is about $123 per share.
  • 6Annual revenue for the most recent period was $1.94 billion and net loss was $2.82 billion.

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