Talphera Cuts Costs and Speeds Trial

Talphera (TLPH) updated investors on its nafamostat mesylate clinical trial at the H.C. Wainwright conference. The NEPHRO study is 75% enrolled, with topline data expected in early 2025 and a potential U.S. launch in late 2025. The FDA reduced the study size to 70 patients, maintaining 90% statistical power. New guidelines recommend nafamostat, and the company sees a larger U.S. market opportunity. The stock has gained 56% over six months, with analysts setting price targets between $3 and $3.50

Talphera (Nasdaq: TLPH) reported Q2 2026 results and a corporate update on nafamostat. NEPHRO CRRT study enrollment is 75%, expected to finish by year-end. KDIGO 2026 draft guidelines cite nafamostat as an acceptable CRRT anticoagulant. Cash and investments were $17.1M at June 30, 2026; Q2 net loss was $4.3M.

TALPHERA, INC. (TLPH) filed an SEC Form 8-K — Results of Operations and Financial Condition. Exhibit 99.1 Talphera Announces Second Quarter 2026 Financial Results and Provides Corporate Update NEPHRO CRRT clinical study of nafamostat is 75% enrolled; expected to be complete this year Draft 2026 KDIGO guidelines added nafamostat as an acceptable CRRT anticoagulant, a posi

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