Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Posts Phase II sac-TMT + Keytruda Data; Plans Phase III

Incyte (INCY) and Genmab (GMAB) are collaborating on a clinical trial to evaluate Incyte's KRAS G12D inhibitor INCB161734 with Genmab's bispecific antibody petosemtamab and standard chemotherapy for metastatic colorectal cancer with KRAS G12D mutation. The Phase 1/2 study will be co-funded by both companies, with Genmab conducting the trial and Incyte providing the clinical supply of INCB161734. This collaboration aims to address a significant unmet medical need in this patient population.

Incyte (INCY) and Genmab will collaborate on a Phase 1/2 trial for KRAS G12D-mutated metastatic colorectal cancer, combining Incyte's INCB161734 with Genmab's petosemtamab and chemotherapy. Incyte will co-fund and supply the drug, while Genmab will lead the study.

GM invested $108M in sodium-ion battery startup Peak Energy and plans to introduce eyes-off driving in its large SUVs and pickups. The automaker aims to compete with Tesla and Chinese manufacturers through software updates and higher-margin services. GM expects digital revenue to grow from $3.2B to $9.6B by 2036, according to UBS.

Humana and UnitedHealthcare are canceling Medicare Advantage plans affecting 1 million seniors. Humana's move impacts 600,000 enrollees, while UnitedHealthcare's decision affects 390,000 members, citing rising costs and demand. Both companies offer alternative plans.

Amazon (AMZN) reported negative $11.6B free cash flow in the trailing twelve months, up from $48.3B two years prior, due to increased capital expenditures. CEO Andy Jassy raised 2026 capex guidance to $220B, citing higher memory costs. Total debt rose to $223B. Q2 revenue grew 20% to $200.6B, while operating income increased 43% to $27.5B. AWS backlog reached $496B, but infrastructure spending may delay positive free cash flow until 2028.

Samsung C&T and POSCO E&C won Seoul apartment remodeling contracts. Samsung C&T secured a 125 billion won project for Banpo Prugio, while POSCO E&C won a 526.4 billion won project for Isu Shindonga Complex 4. Both projects will proceed under private contracts.