Am­gen's Imdell­tra com­bo more than halves risk of death in small cell lung can­cer

Amgen's Imdelltra, combined with AstraZeneca's Imfinzi, reduced mortality risk by 58% in a lung cancer trial. Imdelltra's US list price is around $300,000 per cycle. Analysts project annual revenues exceeding $2.5B by 2030. The drug is approved for extensive-stage small cell lung cancer, with 80% of trial patients alive at one year.

Amgen reported Phase 3 trial results showing IMDELLTRA with AstraZeneca's IMFINZI reduced death risk by 58% in extensive stage small cell lung cancer. Median progression-free survival was 7.4 months vs. 1.9 months. Safety profiles were consistent with known data. Additional data reinforced sustained outcomes. The trial included 563 patients and was sponsored by Amgen with partial funding from AstraZeneca.

Amgen's Imdelltra, combined with AstraZeneca's Imfinzi, reduced death risk by 58% in extensive-stage small cell lung cancer patients, extending median survival to 21.1 months. The trial suggests potential for Imdelltra's earlier use, boosting its commercial prospects with Q2 sales of $288M, up 115% YoY. Amgen aims to position Imdelltra as a backbone therapy for this aggressive cancer.

Amgen (AMGN) announced that IMDELLTRA® combined with AstraZeneca's IMFINZI® reduced the risk of death by 58% in extensive stage small cell lung cancer (ES-SCLC) patients. Median overall survival increased to 21.1 months from 12.7 months with IMFINZI alone. The Phase 3 DeLLphi-305 study results were presented at ESMO Congress 2026 and published in The New England Journal of Medicine.

Amgen's Phase 3 DeLLphi-305 study showed that 80% of patients with extensive-stage small cell lung cancer (ES-SCLC) treated with IMDELLTRA (tarlatamab) and durvalumab survived at one year, compared to 53% with durvalumab alone. The combination therapy also reduced the risk of disease progression or death by 66%. Amgen will discuss these results and its oncology portfolio in an upcoming investor event.

Roche will pay Zymeworks $55M upfront for global rights to ZW209, a trispecific T-cell engager targeting small cell lung cancer, with potential total payments of $813M. Zymeworks' shares rose 5.5% premarket. Roche will fund Phase 1a trials, taking over development and commercialization. ZW209 aims to improve on Amgen's Imdelltra, targeting DLL3, CD3, and CD28. The deal is subject to regulatory approvals.