Taiho and Cullinan’s zipalertinib clears Phase 3, teeing up first-line competition
Taiho Pharmaceutical and Cullinan Therapeutics said their Phase 3 REZILIENT3 trial of zipalertinib plus chemotherapy in first-line advanced NSCLC with EGFR exon 20 insertion mutations met the primary endpoint at interim analysis. They reported statistically significant, clinically meaningful progression-free survival improvement versus chemotherapy alone, without disclosing figures. Zipalertinib is under FDA review for previously treated patients.





