Kyowa Kirin Co., Ltd. And Kura Oncology, Inc. Advance Ziftomenib With Japan Phase 2 Trial In NPM1 Mutated AML
Kyowa Kirin Co., Ltd. and Kura Oncology, Inc. have initiated a Phase 2 registrational clinical trial in Japan for ziftomenib, an oral menin inhibitor aimed at treating relapsed or refractory NPM1-mutated acute myeloid leukemia (AML). This step is crucial for potential regulatory approval in Japan, following its FDA approval in November 2025 for similar patient populations in the U.S. The trial seeks to confirm the drug's efficacy and safety, addressing a significant unmet medical need for AML patients.