Over the last 12 months, Upstream Bio insiders reported no purchases and 15 sales totaling $105K across SEC Form 4 filings.
Scroll the table sideways for price, value and marks.
| Date | Insider | Type | Shares | Avg price | Value | Δ stake | Marks |
|---|---|---|---|---|---|---|---|
| Sep 16, 2026 | Sutherland Everett RandChief Executive Officer · O·D | ▼ Sale | 2,095 | $5.49 | $12K | -3% | — |
| Sep 16, 2026 | Houghton AdamChief Business Officer · O | ▼ Sale | 700 | $5.49 | $4K | -3% | — |
| Sep 16, 2026 | GRAY MICHAELCFO and COO · O | ▼ Sale | 853 | $5.49 | $5K | -3% | — |
| Sep 16, 2026 | Ambrose AllisonGeneral Counsel · O | ▼ Sale | 485 | $5.49 | $3K | -3% | — |
| Sep 16, 2026 | Deykin AaronChief Medical Officer · O | ▼ Sale | 895 | $5.49 | $5K | -2.7% | — |
| Jun 16, 2026 | GRAY MICHAELCFO and COO · O | ▼ Sale | 853 | $6.1 | $5K | -2.9% | — |
| Jun 16, 2026 | Sutherland Everett RandChief Executive Officer · O·D | ▼ Sale | 2,095 | $6.1 | $13K | -2.9% | — |
| Jun 16, 2026 | Houghton AdamChief Business Officer · O | ▼ Sale | 700 | $6.1 | $4K | -2.9% | — |
| Jun 16, 2026 | Deykin AaronChief Medical Officer · O | ▼ Sale | 895 | $6.1 | $5K | -2.6% | — |
| Jun 16, 2026 | Ambrose AllisonGeneral Counsel · O | ▼ Sale | 477 | $6.1 | $3K | -2.9% | — |
| Mar 16, 2026 | GRAY MICHAELCFO and COO · O | ▼ Sale | 852 | $9.29 | $8K | -2.8% | — |
| Mar 16, 2026 | Deykin AaronChief Medical Officer · O | ▼ Sale | 894 | $9.29 | $8K | -2.7% | — |
| Mar 16, 2026 | Sutherland Everett RandChief Executive Officer · O·D | ▼ Sale | 2,093 | $9.29 | $19K | -2.8% | — |
| Mar 16, 2026 | Ambrose AllisonGeneral Counsel · O | ▼ Sale | 475 | $9.29 | $4K | -2.8% | — |
| Mar 16, 2026 | Houghton AdamChief Business Officer · O | ▼ Sale | 699 | $9.29 | $6K | -2.8% | — |
The same Form 4 data over REST or MCP, already grouped into events with the plan flag and the dollar value read. A free key does 100 calls a day and needs no card. Prefer email? Upstream Bio filings can reach your inbox instead.
Corporate insiders — officers, directors and 10%+ owners — must report their trades to the SEC on Form 4 within two business days. This page shows open-market activity: purchases (code P), sales (S) and dispositions back to the issuer (D). Scheduled compensation events such as stock grants and option exercises are also filed on Form 4 but carry no trading signal, so they are not shown and counts here can be lower than the raw EDGAR filing total. We group each filing's transactions into one economic event (a laddered 10b5-1 sale is one event, not 25 rows), flag pre-arranged plans and late filings, and link every event to its AI-scored article in the $UPB feed.