argenx to acquire Unnatural Products for up to $1.15 billion

argenx announced a definitive agreement to buy private biotech Unnatural Products (UNP). The transaction includes a $550 million cash payment up‑front and up to $595 million in milestone payments, bringing total consideration to about $1.15 billion. The deal is expected to close by the end of 2026, subject to customary conditions, and UNP will remain operating from its Santa Cruz site as a peptide‑discovery hub within argenx.

The acquisition adds a macrocyclic peptide platform to argenx’s antibody engineering, expanding its pipeline options for oral and long‑acting immunology therapies (the company says). The transaction will increase argenx’s cash outflow by $550 million now and may require additional milestone payments later.

  • 1Up‑front cash payment of $550 million.
  • 2Potential milestone payments of up to $595 million, for a total possible value of about $1.15 billion.
  • 3Closing expected by the end of 2026, subject to customary closing conditions.
  • 4Unnatural Products will continue to operate from its Santa Cruz, California facility as a dedicated macrocyclic peptide discovery hub within argenx.
  • 5UNP employs more than 50 people.

Sources