Longer Gap Between Doses Boosts Durability of Self-Amplifying mRNA H5N1 Flu
A Phase 1 trial of Arcturus Therapeutics' self-amplifying mRNA H5N1 flu vaccine, ARCT-2304, showed strong immune responses and durability when doses were spaced eight weeks apart. The vaccine, encoding both HA and NA antigens, was well-tolerated across dose levels. The study, funded by U.S. HHS, suggests potential for pandemic preparedness.


