$CRBU

Caribou Biosciences, Inc.

Caribou Biosciences is a clinical-stage biopharmaceutical company developing genome-edited cell therapies for patients with serious diseases. Its chRDNA genome-editing technology uses hybrid RNA-DNA guides, and its current focus is on two off-the-shelf CAR-T cell therapy candidates for hematologic malignancies: vispa-cel, which targets CD19 and is being studied for relapsed or refractory B cell non-Hodgkin lymphoma, and CB-011, which targets BCMA and is being studied for relapsed or refractory multiple myeloma. The candidates are made from healthy donor cells and use genome edits intended to reduce immune rejection and improve cell activity. Caribou is advancing these products through clinical trials and aims to develop, manufacture, and commercialize genome-edited cell therapies. It also identifies potential applications of its technology in other cell and gene therapies, including through strategic collaborations. Caribou is headquartered in Berkeley, California.

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Caribou Biosciences Halts Off-the-Shelf CRISPR CAR-T Programs for Lymphoma and Myeloma After Failing to Fund Phase 3 Trial

Caribou Biosciences, a biotech co-founded by Jennifer Doudna, is halting its off-the-shelf CAR-T therapies (vispa-cel for lymphoma, CB-011 for myeloma) due to funding issues for a phase 3 trial. The company will reduce its workforce and explore strategic options. Caribou had $113.8M in cash as of June 30, but cited a challenging financing environment for donor-derived CAR-T therapies.

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Caribou Biosciences Halts Off-the-Shelf CRISPR CAR-T Programs for Lymphoma and Myeloma After Failing to Fund Phase 3 Trial

Caribou Biosciences, a biotech co-founded by Jennifer Doudna, is halting its off-the-shelf CAR-T therapies (vispa-cel for lymphoma, CB-011 for myeloma) due to funding issues for a phase 3 trial. The company will reduce its workforce and explore strategic options. Caribou had $113.8M in cash as of June 30, but cited a challenging financing environment for donor-derived CAR-T therapies.

Deal Dispatch: Uber Buys ezCater For $2.3B, Skydance Takes Over Warner Bros., True Food Kitchen Bankruptc

Caribou Biosciences (CRBU) is exploring strategic alternatives, including a potential sale, and will discontinue two CAR-T therapy programs. Viatris (VTRS) agreed to acquire Pacira BioSciences for $1.65B. Uber (UBER) will buy ezCater for $2.3B. Skydance (SKYD) completed its acquisition of Warner Bros. Discovery (WBD). True Food Kitchen filed for Chapter 11 bankruptcy.

In the hunt for reverse merger targets, Caribou could be prized game

Caribou Biosciences, a biotech co-founded by CRISPR pioneer Jennifer Doudna, is exploring strategic alternatives, including a reverse merger or acquisition, due to challenging financing conditions. The company has $114M in cash and has hired Wedbush Securities as its financial advisor. Analysts suggest a reverse merger or acquisition by Tang Capital as potential outcomes.

CAR-T specialist Caribou culls pipeline and seeks exit deal

Caribou Biosciences, a biotech developing off-the-shelf CAR-T cell therapies, will discontinue its pipeline and lay off employees, citing shifting investor interest towards in vivo approaches. The company is exploring exit strategies, including mergers or acquisitions. Caribou's board attributes the decision to the current financing environment for allogeneic CAR-T therapies. The company had 97 employees as of February 2026, with substantial layoffs planned.

$STZHighAI 8/10

Constellation Brands, Caribou Biosciences And Other Big Stocks Moving Lower In Wednesday’s Pre-Market Ses

Constellation Brands (STZ) shares fell 5.1% in pre-market trading despite beating Q2 earnings and sales estimates, reporting $3.74 EPS and $2.633B revenue. The company also announced the acquisition of SpikedAde. Caribou Biosciences (CRBU) shares dropped 35.7% after exploring strategic alternatives and discontinuing two cell therapy programs.

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